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Early life and education [edit] Linus Carl Pauling was born on February 28, 1901, in Portland, Oregon, [14] [15] the firstborn child of Herman Henry William Pauling (18761910) and Lucy Isabelle "Belle" Darling (18811926)

M.KaeberleinM.GuarenteL

Nat Rev Mol Cell Biol 2023

Journal of Physiology and Pharmacology, 2008

This cysteine-homocysteinylation event perturbs the pro-insulin receptor and furin protease interaction within the Golgi apparatus, consequently inhibiting the cleavage of the pro-insulin receptor

Furthermore, the role of IGF-1 in attenuating hepatocyte premature senescence mediated by progerin needs further exploration