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Peer-reviewed human clinical trials remain limited, which is a key reason regulatory bodies have not approved the compound for therapeutic use

V., & Bobyreva, S

Another study incorporated kartogenin within MSNs before adding them to a chitosan solution containing PDGF-BB to fabricate composite microspheres aimed at repairing osteoarticular lesions [258]

The transcriptomics data have been deposited in the ArrayExpress database ( under accession number E-MTAB-15583 75

Moreover, intra-articular administration of sprifermin has been applied for patients with acute cartilage injury of the knee (NCT01066871), where treatment outcomes revealed reductions in both defect volume and cartilage defect thickness

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