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Retinol activates nuclear retinoic acid receptors and drives collagen gene transcription, but frequently causes irritation, peeling, and photosensitivity at therapeutic concentrations

Article contents Abstract Introduction Allostery: Theoretical framework of conformational behavior Dynamic communication networks and functional specificity Signaling bias not only in GPCRs but also in all dynamic, allosteric proteins GPCRs and dynamic allosteric proteins share signaling principles Conclusions Author contribution Competing interests References Allostery: allosteric networks and allosteric signaling bias Published online by Cambridge University Press: 18 November 2025 Abstract Introduction Allostery: Theoretical framework of conformational behavior Dynamic communication networks and functional specificity Signaling bias not only in GPCRs but also in all dynamic, allosteric proteins GPCRs and dynamic allosteric proteins share signaling principles Conclusions Author contribution Competing interests References Abstract Allosteric communication is established by networks through which strain energy generated at the allosteric site by an allosteric event, such as ligand binding, can propagate to the functional site

Common Mistakes to Avoid Following best practices during reconstitution prevents costly experimental failures

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Abstract The hypothalamicpituitaryadrenal (HPA) axis, a neuroendocrine network that controls hormonal responses to internal and external challenges in an organisms environment, exhibits strikingly sex-biased activity