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5 Age-related retinal degeneration and its relation to phase separation The cells of all tested living organisms depend upon phase separation, a spontaneous thermodynamic process enabling fluid, reversible cellular compartmentalization, to rapidly organize/reorganize functions/reactions in response to the fluctuating cellular environment (96)

doi:10.1093/brain/awm129 82

and (8) the clinical efficacy in severe DPN patients remains unverified

Mitochondrial problems were present as early as P15 (postnatal day 15) 17 , and they were also observed in the upper motor neurons (UMNs) of a broad spectrum of ALS patients with TDP-43 pathology 16
