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glutathione conjucation Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation Schematic representation of and crosstalk
Description
The glutathione detox pathway is not just about oestrogen

(1995) Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV

doi: 10.1101/cshperspect.a019505 155 DaviesHBignellGRCoxCStephensPEdkinsSCleggSet al

2020 May 22;11(5):390
In contrast, when 2 and 5 Gy of X-irradiation was applied to the cells at 12 h after cell sorting, ZsG + cells exhibited a higher survival fraction than ZsG cells in MegTCCZsG (2 Gy, 0.54 0.02 and 0.79 0.06, p = 0.001

In this context, it should also be noted that xCT overexpression is associated to cognitive deficits [71, 72] supporting the idea of a plausible connection between these two events
