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In Vitro and Animal Models for SARS-CoV-2 research

A high-fat diet (HFD) alters the composition of the intestinal flora, leading to decreased expression of TJ protein, increased intestinal permeability, translocation of bacteria and bacterial products, and generation of systemic chronic low-grade inflammation leading to metabolic disorders (Wang et al., 2020)

10.1021/bi00437a023 [DOI] [PubMed] [Google Scholar] Brimecombe JC, Potthoff WK, & Aizenman E (1999)

G-actin sequestering peptide

Glutamine can also undergo glutathionylation, a process of glutamine-protein modification, which is highly conserved in all metazoans and protists and plays a vital role in many physiological and pathological processes [136]

Abnormal intestinal permeability precedes the onset of CD by 3 years and may be an important component of pathogenesis