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The ratio of Firmicutes to Bacteroidetes is a commonly-studied change with an increase often linked to HFD consumption/obesity in mice 43,44 and humans 45,46 (for review, see John and Mullin, 2016 47 )

Um, it's also hypothesized to increase ni uh, nitric oxide, which is a, uh, blood vessel dilator, uh, improving microcirculation

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This effect may be attributed to increased activity of the checkpoint kinase Chk1, which is only observed in cells treated with low-dose etoposide