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734434 and FAR 2015 of the Department of Life Sciences, UNIMORE

[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Stern R

This phosphorylation event decreases the enzymatic activity of PDH, preventing the conversion of pyruvate to acetyl-CoA

These include oxidized LDL (ox-LDL), cholesterol crystals and calcium phosphate crystals in the former case, as well as HSPs, HMGB1, ATP, nuclear and mtDNA, and RNA in the latter one [134]

Importantly, MKR mice exhibit defects in the free fatty acid (FFA) oxidation pathway, which leads to elevations in serum FFAs and triglycerides (TGs), as well as increased TG deposits in liver and muscle tissues, suggesting that hyperlipidemia and accumulated lipids in tissues may be causative factors for the progression of type 2 diabetes in MKR mice, replicating human cases with inherited lipodystrophy or dyslipidemia (37, 38)

It has been shown that cannabis has compounds with immunomodulatory and antioxidant functions in other pathologies