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This high binding capacity allows FR to transport folate against a concentration gradient at levels as low as 0.1 nM [5, 26], roughly ten times lower than required transport via RFC [2, 3], making it the most efficient plasma membrane folate transporter identified

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Besides, the microorganisms secrete an entire set of proteases, instead of one or several, which makes proteins in substrates adequate and shortens the production cycle of peptide-based products (Song et al., 2023)

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