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High concentrations of Met are needed to activate T cells and maintain their activation status (85), which indicates that hypermethioninemia promotes T-cell activation

Post-translational Regulation of ACO An in vitro phosphorylation assay using protein extracts of pre- and post-climacteric apple fruit and an ectopically expressed His-tagged Md ACO1 (MDP0000195885) hinted for the first time that ACO protein-protein interactions could exist (Dilley et al., 1995)

Tumor-derived cytokines such as IL-6, growth arrest specific protein 6 (GAS6), HGF and EGF can promote resistance to targeted therapy through autocrine signaling [64]

10.1016/j.jgr.2021.06.004 8 ChoiY

The current review focuses on Se transport to the brain, including, first of all, selenoprotein P/low-density lipoprotein receptor-related protein 8 (LRP8, also known as apolipoprotein E receptor-2) dependent pathway, and supplementary transport routes of Se into the brain via low molecular weight Se-species

Iron ions are essential for cell metabolism and survival, but excess free iron ions lead to increased intracellular oxidative stress, which promotes cell death, especially ferroptosis [42, 43]