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An alteration in the phosphorylation pattern, such as an increase in tyrosine phosphorylation, which results from pathological conditions, such as inflammation or elevated ROS, can alter the proteinprotein interactions of occludin with ZO-1, ZO-2, and ZO-3, and thereby alter the membrane integrity 75

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Gantz BJ, Fisch U

Elevation of plasma 2,3-BPG over time suggested release from RBC, possibly via minor hemolysis

Abuse, violence, neglect, food scarcity are common types of toxic stress sources All these sources can also be considered as risk factors in the development of PTSD

10.1016/s0002-9394(02)02156-6 Am