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Clinical trials have consistently demonstrated that this restoration leads to a dramatic, measurable reduction in specific biomarkers of systemic oxidative damage, such as TBARS (thiobarbituric acid reactive substances) and F2-isoprostanes, which are direct indicators of lipid membrane destruction

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Funding This work was supported by the St

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In a phase III trial in unselected patients with metastatic pancreatic cancer, a combination of ganitumab plus gemcitabine had manageable toxicity but did not improve OS compared with gemcitabine alone [123]

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spermatogenesis and sperm maturation

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C., Lui, M

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KO, n = 5

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