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A combination of automated and manual rebuilding and refinement in Refmac 29 and COOT 30 were used to produce the refined models

There is considerable literature about the oddities of the prescribing habits of British doctors , the factors influencing them, and the attitudes of doctors to prescription, but there have been as far as we know, no attempts to compare quantitatively the expected amount prescribed, on the basis of good clinical practice, with that actually prescribed

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Consulting a healthcare professional or dermatologist is always recommended to ensure the safe and effective use of any skin whitening tablets