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On one hand, targeting ferroptosis may provide a promising direction for the development of drugs for chronic atrophic gastritis (CAG) and intestinal metaplasia (IM)

Ashraf et al., Labile Iron Pool and Its Role in Ferroptosis Increased LIP can lead to the generation of reactive oxygen species via Fenton reaction, eventually resulting in catastrophic membrane rupture (Kakhlon and Cabantchik, 2002

have been shown to alleviate colitis by modulating the inflammatory response and increasing the levels of PPAR- (Zhang W

10.3389/fneur.2022.834329 [DOI] [PMC free article] [PubMed] [Google Scholar] Zamponi E., Zamponi N., Coskun P., Quassollo G., Lorenzo A., Cannas S

Contribution of nad(P)H:Quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors

2.3Nonalcoholic fatty liver disease and NRF-2 To define nonalcoholic fatty liver disease, it should be proven, by means of an image or a histological method, that the steatosis is not related to any secondary cause that conditioned the accumulation of liver fat, such as alcohol consumption, infection by hepatitis C virus, or any congenital metabolic disorder, steatogenic medications or among other causes