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Drosophila melanogasteran embryonic model for studying behavioral and biochemical effects of manganese exposure

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Omega-3 PUFAs, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have anti-inflammatory and antioxidant properties that reduce oxidative stress and protect against ferroptosis by incorporating into cell membranes, stabilizing phospholipids, and reducing their vulnerability to peroxidation (Suda et al., 2024)

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This cooperative regulation ensures that the hypoxic response is precisely controlled, preventing the detrimental accumulation of ROS that impairs osteoblast survival and BMSC differentiation