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SAM stops being drained by the methylation step, so methyl-group supply recovers

While systemic dihexa half life remains one to two hours, CNS concentrations may persist for four to six hours because the peptide is delivered to the target site without requiring blood-brain barrier penetration

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doi: 10.1093/qjmed/hcn123 560 JonesJFNicholsonANisenbaumRPapanicolaouDASolomonLBonevaRet al

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