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This small molecule compound demonstrates exceptional ability to block nicotinamide N-methyltransferase enzyme activity, preventing NAD+ depletion while activating sirtuin pathways associated with healthy aging and metabolic optimization

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This creates an interesting mechanistic distinction

To validate NNMT as an anti-obesity drug target, we investigated the permeability, selectivity, mechanistic, and physiological properties of a series of small molecule NNMT inhibitors

Fat loss and body composition This is the headline, and it has two anchor studies

5-amino-1mq appears to have muscle-sparing properties