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Conclusion: AAPE activates HK proliferation and migration

CVD and Oxidative Stress

Aconitase is highly sensitive to inactivation by superoxide because of its labile iron atom and its proximity to the superoxide-generating electron transport chain

At a molecular level, this results in the release of neurotransmitters, particularly nitric oxide (NO): NO is synthesized by the NO synthase enzyme (NOS), and particularly by two isoforms of this enzyme present in nerve terminations (neuronal NOS

Statements Author contributions LY: Conceptualization, Investigation, Project administration, Visualization, Writing original draft, Writing review & editing

Complement Most straightforward is the inclusion of complement in neutralization assays