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472 Notably, mitochondrial damage and immune checkpoint expression form a positive feedback loop

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A.Maria-MacedoA.Silva-MartinsS.Custodio-SilvaA

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Furthermore, phytochemicals facilitate receptor-mediated endocytosis of NPs by acting as biocompatible capping agents

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This leads to the transcription of genes involved in detoxification, antioxidation, and anti-inflammatory responses ( Figure 2 ) (90)

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