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The other is an indirect interaction through the release of metabolites, including SCFAs, which can influence physiological responses through different signaling pathways (58)

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It also plays a role in bile salt formation for digestion and helps regulate water and mineral balance within cells, contributing to overall hydration and electrolyte balance

Additionally, they experienced headaches 45% of the time with a placebo, with the study ultimately finding aspartame to be no better at inducing headaches than a placebo