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Description
Metformin activates AMPK through mitochondrial complex I inhibition at a low, steady level
They are most valuable for patients who are already committed to lifestyle changes but need additional support to see consistent results
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The statistical imputation recodes missing functional status data to a likely value had the status been assessed, whereas the current imputation approach implemented in existing function outcome measures recodes missing data to the lowest functional status
The majority of the pathogenic mutations are located in exon 5-6 of the gene
PMID 8031323
