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Vaccines 9(10):1129

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Critical differences in the gating of dimeric MYO5 compared with artificially dimerised MYO6 have shown the importance of rate limiting and load-dependent ADP (MYO5) 34,48,49 versus ATP (MYO6) 33,45,50,51,52,53 exchange for these myosins, with load affecting nucleotide exchange on lead and trail heads differently, consistent with MYO5 operating as a processive transporter, while MYO6 can act both as a transporter and an actin-based anchor 12,45,54

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