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Tiotropium treatment for bronchiectasis: A randomised, placebo-controlled, crossover trial

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Respire 2: A phase iii placebo-controlled randomised trial of ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis

1 Introduction Despite decades of intensive research and substantial investmentwith Alzheimers disease alone projected to surpass 1 trillion USD in global cost by 2050 (Nandi et al., 2024), therapeutic progress in neurodegenerative disorders has remained limited, with most clinical approaches continuing to target downstream proteinopathies and yielding only modest effects on disease trajectories (Selkoe and Hardy, 2016