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The antioxidants in Alpha Lipoic Acid have been shown to fight damage from cigarette smoke

Clin Toxicol (Phila) 2020;58:80412 [DOI] [PubMed] [Google Scholar] 28.Coen M, Lenz EM, Nicholson JK, Wilson ID, Pognan F, Lindon JC.An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy

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doi: 10.1111/jcmm.17184

In addition, ATP, a ligand of P2XRs, being released from primary afferent neurons can activate glial cells via C-fiber stimulation, while activated glial cellsparticularly microgliacan induce LTP (148150)

Chronic inflammation is a hallmark of neurodegenerative diseases like PD