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In addition, reduced serum testosterone levels in men with DM are an independent factor of endothelial dysfunction, contributing to vascular disease and ED [78], and evidence also showed a decrease in circulating EPC correlates with penile endothelial dysfunction and testosterone levels in DM-associated ED [79]

3 Cardiovascular disease and gut microbiota 3.1 Overview of CVD Nowadays, CVD has emerged as the leading cause of morbidity and mortality worldwide

This was a marked improvement as compared with the findings in historical controls, and this and similar studies led to the widespread acceptance of acetylcysteine for the prevention of hepatic injury due to acetaminophen overdose

10.3390/nu12092664 18
