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Other possible vitamin B12 shot side effects include: Headache Dizziness Rash Facial flushing Skin redness Cold symptoms Anxiety Swelling Diarrhea Vomiting High blood pressure How to Prevent The best way to avoid the potential side effects of too much vitamin B12 is to get the majority of your vitamin B12 from nutrient-rich food sources, including meat, poultry, seafood and dairy products