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The flat normal distribution also has a high variance, which makes sense because the standard deviation is the square root of variance

Biophysical Journal

Of note, p53 R270H but not p53 R172H also acted in a dominant-negative manner in promoting tumorigenesis when the other allele was WT for p53

SIRT1SEC controls MED1 IDR deacetylation upon stress Sirtuin-class deacetylases regulate histones and numerous nonhistone proteins involved in transcription regulation 16