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Note: Despite all advances in stem cells research and the application of these therapies in many countries all over the world, stem cell therapies are not legally approved yet in San Diego, Los Angeles, Chicago, Dallas, New York, Jacksonville, Seattle, Houston, San Francisco, Salt Lake City, Miami, Beverly Hills, and other US cities

Additionally, GSEA analysis of iSPN + mut at 3 months revealed a significant reduction in the expression of genes associated with the first stage of the cellular respiration process glycolysis and the tricarboxylic acid cycle, followed by a further decrease at 8 months (Supplementary Table 1b,c,e,f)

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(100) shiitake mushrooms were exposed to intermittent and single ozone treatments, then stored at a temperature of 4C for a period of 14 days with 90% relative humidity demonstrating that periodic application at the ideal dosage of 3.2 mg/m 3 outperformed the single treatment preserving proteins and phenolic compounds, inhibiting polyphenol oxidase activity to inhibit the occurrence of surface discoloration and decreasing the accumulation of unbound amino acids within the mushrooms

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