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Crossing the blood-brain barrier: glutathione-conjugated poly(ethylene imine) for gene delivery

Blcsatornnkban rintkeznk a legnagyobb felleten klvilg anyagaival, vegyszereivel s krokozival is

10.1016/j.ejphar.2023.175917 101 QuY.LiJ

GSH is found throughout cellular compartments in millimolar concentrations (110 mM)

Andrographolide can lower the expression of NO and proinflammatory cytokines, such as IL-6, TNF-, and IL-1 to alleviate dextran sulphate sodium salt (DSS)-induced acute colitis in mice, and its mechanism is associated with the inhibition of the NF-B and MAPK pathways in colon tissue and the activation of the AMPK pathway (Zhu et al., 2018b)

Under normal circumstances, mitochondrial glutathione rapidly neutralizes these byproducts
