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Unsurprisingly, most clinical trials with NAC have demonstrated a lack of efficacy [12-16]
The ability of taninins to protect the liver from damage caused by APAP has also been looked into
For example, a shift in ratio towards the oxidized pool has been shown to induce glutathionylation of the cysteine located in the DNA binding site of c-jun as well as produce a disulfide bond between cysteines proximal to the leucine zipper motif
The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression
Chen J, Jiang Y, Shi H, Peng Y, Fan X, Li C
Spilmont et al., 2015)
