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While surgical interventions (e.g., temporal lobectomy or laser ablation) may benefit select patients with focal epileptogenic zones, inherent risks of neurological deficits and variable efficacy underscore the need for alternative therapeutic strategies (23)

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Oral and injectable formulations of existing drugs often exhibit poor bioavailability, systemic toxicity, and suboptimal patient adherence due to frequent dosing and adverse effects (e.g., gastrointestinal distress and rashes) (Yang Y

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