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Using retinal homogenates collected from adult zebrafish developmentally exposed to BPA, we used Western blots to assess activation (phosphorylation levels) of the three MAPK families (ERK, JNK, P38) and AKT, the primary regulator of downstream PI3K/AKT pathway effectors

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It was also verified that one kind of long noncoding RNA, LINC00662, could activate the Wnt/-catenin pathway in an autocrine manner by increasing Wnt3a expression and secretion, and also in a paracrine manner to promote M2 macrophage polarization, leading to HCC tumorigenesis and metastasis in vivo 27 ( Figure 2 )

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