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Laboratory findings suggest TB-500 could engage with the globular form of actin (G-actin) and potentially reduce its polymerization into filamentous actin (F-actin)

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Thus, an alternate cell-intrinsic hypothesis might explain the immunoenhancing effect of CD38 mAbs combined with IMiDs

Those with deficiencies may need up to 1,000 mcg daily until levels normalise, then maintenance doses of 25-100 mcg