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Notably, Nrf2 translocates to the nucleus in ROS-sensitive cells, increases the antioxidant HO-1 levels, decreases the MDA levels, and increases the SOD and GSH activities (Xie et al., 2023

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Compared to glycolysis, intermediates of the TCA cycle, namely succinate and citrate, support biosynthesis in M1 macrophages (11)