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While diagnostic uses for measuring total hemoglobin mass or pulmonary diffusion capacity remain permitted, using CO to artificially increase oxygen-carrying capacity is now explicitly banned

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( A - C ) Same UMAP of the myogenic subset as in Fig

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Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine