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7 Challenges and future directions 7.1 Safety and offtarget effects One major hurdle in leveraging ferroptosis for AML therapy is the potential toxicity to normal tissues, especially hematopoietic stem and immune cells, due to systemic iron overload and lipid peroxidation [38, 160]

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Glutathione and its precursor NAC can help with this

Barzegar M, Wang Y, Eshaq RS, Yun JW, Boyer CJ, Cananzi SG, Alexander JS (2021) Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow

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