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The maintenance of a functional colonic mucosal barrier is essential to guarantee a healthy condition and the luminal confinement of bacteria is one of the key roles of the gut mucosa

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The main purpose of glucose metabolism is to generate lactate, which can store a vast amount of carbon, resulting in a reduction of carbon sources entering the TCA cycle and a continuous flow of intermediate TCA cycle products into the cytoplasm for the synthesis of biological macromolecules, such as lipids, nucleotides and proteins