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But Increased GH and IGF-1 Are Not a Free Upgrade Endocrine changes at this scale come with potential trade-offs: Fluid retention Glucose regulation concerns Possible long-term diseases questions linked to IGF-1 elevation (Holt, 2025

Supplements may be recommended as part of a broader plan that includes nutrition guidance, lifestyle adjustments, and ongoing wellness support

Severe autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy in an adolescent girl with a novel AIRE mutation: response to immunosuppressive therapy

Mller IM, Rogowska-Wrzesinska A, Rao RSP

Sinauer Associates

NAD and energy metabolism : Shown to increase intracellular NAD levels by up to 1.6-fold, supporting mitochondrial function and cellular energy production
