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In lung cancer, ROS generated by cigarette smoke cause DNA mutations and contribute to the activation of pro-inflammatory cytokines that promote tumorigenesis

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doi: 10.1002/mc.23497 20 YucelBAdaS

Apart from local inflammation, activation of glial cells (satellite glial cells, Schwann cells and immune cells) in the DRGs are also involved in the augmented inflammatory responses and enhanced neuronal excitability resulting in the development of pain hypersensitivity after chemotherapy treatment (Fumagalli et al., 2020)

[DOI] [PMC free article] [PubMed] [Google Scholar] 132.Delettre C, Yuste VJ, Moubarak RS, Bras M, Lesbordes-Brion JC, Petres S, et al

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