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Li K, Zhou G, Xiao Y, Gu J, Chen Q, Xie S, Wu J

R., Schulte R., Le P., Butsch W

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Retatrutide is a synthetically engineered 39-amino-acid peptide developed to activate three separate G protein-coupled receptors (GPCRs): Glucose-Dependent Insulinotropic Polypeptide (GIP) receptor Glucagon-Like Peptide-1 (GLP-1) receptor Glucagon (GCGR) receptor Because it interacts with all three pathways simultaneously, researchers commonly describe Retatrutide as a triple receptor agonist rather than a single or dual-pathway peptide

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As of March 2026, two trials are actively recruiting new participants: the Maintenance trial (NCT06859268, testing dose reduction after initial weight loss) and a new enrollment trial (NCT07232719, 250 participants with obesity or overweight)