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Proc Am Assoc Cancer Res 38:137, 1997

The termination of the EAA action takes place by an uptake mechanism that uses the Na + , K + and pH gradients as a driving force to translocate the neurotransmitters against their concentration gradients, keeping their concentration below the level that activates their receptors (~1 mM) [13-15] (Figure 2)

The disease is spontaneous, is associated with a relatively low frequency within the colony and lesions that wax and wane, making it an interesting observation but not a model that is readily amenable to experimental manipulation

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In addition to diagnosis, it can be used to guide treatment decisions [34]

Interestingly, in Arabidopsis suspension cells transcriptional up-regulation of GCL in response to various oxidative stresses was not observed, even though both GCL activity and cellular glutathione levels increased (May et al., Localization of Glutathione Synthesis in Plants The localization of GCL and GS plays a major role in the biosynthesis of glutathione