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In extreme instances, symptoms can include seizures, coma and respiratory failure

The possible mechanisms might be the biologic and molecular pathways include enhanced insulin sensitivity, increased high-density lipoprotein (HDL) cholesterol, and improved endothelial function by decreased tissue injury via limited ischemia/reperfusion ratio induced by ethanol 35,37

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All patients had hypertelorism, blue sclera and spinal deformities such as kyphoscoliosis or scoliosis [7]