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Description
This process is essential in disorders of mitochondrial fatty acids oxidation where the fatty acyl-CoAs accrual in specific tissues such as in the heart and central nervous system can induce toxicity, trigger apoptosis and inflammation, and destabilize mitochondrial membrane [17,18]
The results mirrored those of random neuronal differentiation, with MFN2 overexpression significantly enhancing NSC differentiation into DA neurons, including increasing the number of branches per neuronal filament (Fig
It is usually well tolerated, but rare serious complications such as VPA-induced hepatotoxicity (VHT) and VPA-induced hyperammonaemic encephalopathy (VHE) may occur in some patients who receive VPA chronically [133]
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[5] As a popular ornamental fish, it was introduced to Great Britain in 1874 [9] and is now widespread in England and Wales, but only has a localised distribution in Scotland
N., Khan M
