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It has been suggested that aldosterone synthase, aldosterone receptors, and the ACE2/angiotensin 1-7/Mas receptor axis are all potential therapeutic targets (193)

doi: 10.1021/acschembio.2c00897

& Sharkey, T
In diabetic state, hyperglycemia leads to overproduction of free radicals (i.e., mitochondrial , NO and peroxynitrite) mainly derived from glucose oxidation and lipid peroxidation, which cause oxidative damage to biomolecules

10.1073/pnas.95.10.5607 114

PCR amplification was performed using the iTaqTM Universal SYBR Green Supermix (Bio-Rad, USA) via the ABI Prism 7500 Fast Sequence Detection System (Applied Biosystems, Foster City, CA, USA)
