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Hypothyroidism (underactive thyroid) is a common cause of cold intolerance in the general population and should be excluded if symptoms are persistent (NHS)
it can also act as a natural diuretic

Babbin, A

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The question worth asking before attributing anhedonia solely to the GLP-1: what else is in the protocol, and what is it doing to the same systems already under pressure

Hydroxocobalamin It is very useful to lower high levels of nitric oxide (common with auto-immune disorders, fibromyalgia, and chronic fatigue)
