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Free radicals cause various types of damage, including single- or double-stranded breaks in DNA, and eventually activate proteins such as the phosphorylated form of checkpoint kinase ataxia telangiectasia mutated (ATM) in the cells

H 2 O 2 treatment increased the amount of oxidative modifications for both Zn 2+ -coordinating cysteines ( Figure 6C )

The deletion of both genes renders yeast cells sensitive to oxidative stress (paraquat) and especially sensitive to osmotic shock (Pahlman et al., 2001)

Diabetes, obesity & metabolism

FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway

The effects of epigenetics play out in the cell membrane