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They were placed in a well-ventilated room (four rats per cage) at a constant temperature (22C26C, 45%75% relative humidity) with a 12-h light/dark cycle in a specific pathogen-free environment

Sep 25 2020;doi:10.1093/ijnp/pyaa070 Fontana A, Manchia M, Panebianco C, et al

air pollution including fine particulate matter (PM2.5), polycyclic aromatic hydrocarbons (PAHs), and nitrogen dioxide (NO2)

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It accumulates and damages macromolecules through secondarily derived ROS (hypochlorous acid, hydroxyl radical and chloramines)

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis