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Neutrophil elastase: alpha-1-proteinase inhibitor complex in serum and bronchoalveolar lavage fluid in patients with pulmonary fibrosis

Specifically, our findings across both clinical cohorts and experimental models demonstrate that hepatic FPN downregulation in MASLD led to iron accumulation, which subsequently and profoundly altered hepatokine secretion profiles, particularly of fetuin-A and LECT2 via FoxO1 activation, ultimately promoting obesity, IR, and impaired thermogenesis

Our findings underscore the critical role of the BRD4-ASXL1 interaction in bridging BRD4 to the ASXL1-bound genomic sites and reveal a high level of correlation between ASXL1 and BRD4 in malignancies

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Scotter et al

In vitro challenge with Mycobacterium avium demonstrated enhanced immune clearance post-treatment, suggesting that glutathione primes immune defense mechanisms relevant to neuroinflammatory conditions