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Deiodinase 3 (D3) is negatively regulated by LPS in the PVN of mice and in cultured neuroblastoma cells, leading to increased intracellular T 3 levels in these cells (67, 68)

The continuous generation of ROS in an environment rich in oxygen increases the risk of oxidative damage.Rich in Polyunsaturated Fatty Acids (PUFAs): Neuronal membranes are abundant in PUFAs, which are highly susceptible to lipid peroxidation caused by ROS

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The statistical analysis plan pre-specified multiple analysis-sets for the primary endpoint, which included both the actual observed data and data sets of all study subjects (including missing data using different pre-specified imputation methods)

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