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It was shown that the SAL1-PAP pathway is important for the organelle-nuclear retrograde signaling in this context
Lipoic acid as an antioxidant: the role of dihydrolipoamide dehydrogenase

Mod Rheumatol

Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel PS, Kohmura E

This arrangement is also found in the pco determinant but with an additional gene, pcoE , further downstream

however, when handled as a research chemical: Effects are dependent on concentration, exposure conditions, and experimental model High concentrations in vitro may alter cellular redox balance and produce unintended experimental outcomes Long-term effects in experimental systems depend on study design and conditions Handling Precautions: Use appropriate personal protective equipment (PPE) including gloves, lab coat, and eye protection Avoid inhalation, ingestion, or direct contact with skin and eyes Handle under controlled laboratory conditions using standard safety protocols Regulatory Status: Not approved by the U.S
